| Aliases: | Suboxone |
| Indications: | Acute withdrawal from opioids |
| Contraindication: | Methadone use within 48 hours, COWS score less than 5 |
| Concentrations: |
| Sublingual | 8 buprenorphine/2mg naloxone per tab |
| |
| Adult Dosing |
| Indication | Dose | Route | Note |
| Acute withdrawal | 16mg | SL | Patient needs to not swallow their spit for 30-60 seconds to allow for absorption. Any drug swallowed is not effective. Can repeat ½ dose after 10 minutes if still symptomatic. |
| |
| Pediatric Dosing |
| Indication | Dose | Route | Note |
| NONE | NONE | NONE | NONE |
| Use Handtevy or Approved Pediatric Reference Guide for Amount to Administer |
|
| Precautions: | On methadone |
| Adverse/Side Effects: | Can trigger acute withdrawal if the COWS score is low. Symptoms include nausea, vomiting, diarrhea, malaise. |
| Class: | Analgesic Opioid Partial-Mixed Agonists, opioid type |
| Mechanism of Action: | Naltrexone has high binding affinity and low activation at the opioid receptor, cravings and withdrawal for opioids are decreased while preventing a person from getting high and relapsing on another opioid. Naloxone prevents IV abuse of suboxone. |
| Onset of Action | 10 minutes | Peak Effect | 1 hour | Duration of Action | 24 hours |
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CHEMS Field Treatment Guidelines 