Blood Transfusion Reaction

Assessment 
Pediatric Pearls: Signs & Symptoms: Differential: 
□ Hypotension: (SBP < 70+ 2x Age in years)  □ Hives
□ Respiratory distress
□ Airway swelling
□ Increased temperature
□ Respiratory failure 
□ Hypovolemia 
□ Trauma 
□ Tension pneumothorax 

Clinical Management Options

EMT-B
• BLS airway management 
• Keep patient supine and warm 
• Administer Oxygen via NRB
Paramedic
• Stop the transfusion, flush the line.
• Keep the blood with the patient for testing
• Consider Tylenol if the patient is alert and protecting their airway
• Give Benadryl IV for skin changes/hives
• Consider IM epinephrine for anaphylaxis in patients who have airway changes, changes in mental status with skin changes (hives)
• ETCO2 assessment 
• Advance airway management as needed 

Contact Medical Control as needed

Pearls 

  • Transfusion reaction is much lower when transfusing in hemorrhagic shock, although not impossible. Early recognition and treatment is critical.
  • Classic symptoms of hemolytic transfusion reaction are fever, flank pain, and red/brown urine. Other symptoms include chills, hypotension, back pain, renal failure.
  • TRALI-Transfusion related acute lung injury is an acute reaction to a blood transfusion where patients rapidly develop non-cardiogenic pulmonary edema. Often associated with fevers/chills.
  • If a transfusion reaction is suspected, the primary treatment is to stop the blood transfusion. Continue transport and make sure the receiving team is aware.