Aspirin

Aliases: Bufferin, Zorpin  

Indications: Chest Pain from suspected Acute Coronary Syndrome/STEMI/ACO 

Contraindications: Anaphylaxis, known ulcer & active GI bleeding

Concentrations: 

Tablet: 81 mg

Dosing

Adult:

Indication	Dose	Route	Note
Suspected ACS or STEMI	324mg	PO	may give full amount if already taken earlier in the day

Pediatric:

Indication	Dose	Route	Note
None

Precautions: 

On blood thinners. 

Pregnancy Category D: There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).

Adverse/Side Effects: N/V, diarrhea, heartburn, GI bleeding 

Class: Analgesic, Antipyretic, NSAID, platelet inhibitor   

Mechanism of Action: Inhibits the formation of prostaglandins associated with pain, fever, and inflammation. Inhibits platelet aggregation by acetylating cyclooxygenase permanently disabling it so that it cannot synthesize prostaglandins and Thromboxanes. Since Thromboxane A2 is important in clotting its absence does not allow blood to clot effectively.  

Onset of Action	Peak Effect	Duration of Action
< 1 hour	1-2 hours	4-6 hours